535952-64-8Relevant academic research and scientific papers
Syntheses of guanidinoglycosides with the inventive use of Mitsunobu conditions and 1,8-diazabicyclo[5.4.0]undec-7-ene
Lin, Peishan,Cher Hui Heng, Sabrina,Sim, Mui Mui
, p. 255 - 261 (2007/10/03)
A series of novel guanidinoglycosides was successfully synthesized. This was accomplished with the use of Mitsunobu conditions as a strategy to convert the glycopyranose anomeric hydroxy group to give the corresponding substituted masked guanidines in high yields. Subsequent deprotection and coupling with Fmoc protected β-amino acid, afforded a series of N,N′-substituted-methyl-isothioureas. Cleavage of Fmoc followed by concomitant cyclization was achieved with a catalytic amount of DBU to give the guanidinoglycosides.
