535961-78-5

Basic information

• Product Name: Benzoyl chloride, 2-fluoro-6-methyl- (9CI)
• Synonyms: Benzoyl chloride, 2-fluoro-6-methyl- (9CI);Benzoyl chloride, 2-fluoro-6-Methyl-
• CAS NO: 535961-78-5
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.5840432
• Product Categories: ACIDHALIDE
• Mol File: 535961-78-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 204.9°C at 760 mmHg
• Flash Point: 77.7°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.257mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: Benzoyl chloride, 2-fluoro-6-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-fluoro-6-methyl- (9CI)(535961-78-5)
• EPA Substance Registry System: Benzoyl chloride, 2-fluoro-6-methyl- (9CI)(535961-78-5)

Safety Data

• Hazardous Substances Data: 535961-78-5(Hazardous Substances Data)

Usage

General Description

Benzoyl chloride, 2-fluoro-6-methyl- (9CI) is an organic compound with the molecular formula C?H?ClFO. It is a member of the benzoyl chloride family and contains a fluorine and methyl group in its structure. This chemical is used in the synthesis of various pharmaceuticals and agrochemicals, as well as in the production of certain polymers and dyes. It is a highly reactive compound that is known for its strong acylating properties, which make it useful in the production of a wide range of organic compounds. However, it is also highly toxic and poses a risk to human health and the environment, requiring careful handling and disposal.

InChI:InChI=1/C8H6ClFO/c1-5-3-2-4-6(10)7(5)8(9)11/h2-4H,1H3

Upstream product

• 90259-27-1 2-fluoro-6-methylbenzoic acid 

Downstream Products

• 1713240-67-5 N-(5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide 
• 1346623-17-3 (2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide 
• 1599475-08-7 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide 
• 1283597-43-2 methyl 4-(2-fluoro-6-methylbenzamido)benzoate 
• 1283597-06-7 2-fluoro-6-methyl-N-(4-(5,6,7,12-tetrahydrodibenzo[b,g][1,5]diazocine-6-carbonyl)phenyl)benzamide 
• 1283597-44-3 4-(2-fluoro-6-methylbenzamido)benzoic acid 

Relevant articles and documents

SYNTHESIS OF CRAC CHANNEL INHIBITORS

A convergent synthetic method for the production of CRAC channel inhibitors is described herein. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

C5aR ANTAGONISTS

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a recepto