535969-72-3Relevant academic research and scientific papers
Synthesis of an ethidium nucleoside and its acyclic analog
Amann, Nicole,Wagenknecht, Hans-Achim
, p. 1685 - 1690 (2003)
The protected ethidium nucleosides 8-(3′,5′-di-O-benzoyl-2′-deoxy-D-ribofuranosyl)-3- acetamido-5-ethyl-6-phenyl-phenanthridinium (5), 8-(3′,5′-di-O-acetyl-2′-deoxy-D-ribofuranosyl)-3- acetamido-5-ethyl-6-phenyl-phenanthridinium (6), and the acyclic analog 8-[(3R)-1,3-dihydroxy-4-yl]-acetamido-3-amino-5-ethyl-6-phenyl- phenanthridinium (3) were prepared. Based on to their different stability, only the acyclic derivative 3 seems to be suitable for oligonucleotide synthesis. Furthermore, the acyclic ethidium nucleoside analog 3 exhibits comparable absorption and emission properties of the underivatized ethidium (1).
