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• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Synthesis, characterization, and structural studies of nickel(II) complexes of some new substituted acid hydrazides

The syntheses, spectroscopic, magnetic, and antimicrobial and theoretical studies of a new series of hydrazides; RCOCH2CONHNH2 (R = CH3, C3H7, C6H5) variously described as acetoacetic (AAAH), butyrylacetic (BUTAH) and benzoylacetic (BENZAH) acid hydrazides and its nickel(II) complexes are reported. Microanalyses, room temperature magnetic susceptibility measurements infrared and electronic reflectance spectra are consistent with a distorted six coordinate octahedral geometry for the complexes. The modeled compounds using semi-empirical method PM3 and density functional theory (DFT) shows a good correlation of crystallographic data. The compounds show appreciable activity against gram +ve and gram-ve bacteria. Copyright Taylor & Francis Group, LLC.

Synthesis, characterization and quantum chemical studies of some Co(II) and Cu(II) complexes of acetoacetic acid hydrazide

New complexes of cobalt(II) and copper(II) acetoacetic acid hydrazides have been synthesized and characterized by elemental analysis, infrared and electronic reflectance spectra and room temperature magnetic susceptibility measurements. The infrared spectra of the complexes revealed the coordination to the metal ion occurs at the carbonyl oxygen and the amino nitrogen of the hydrazide moiety. This was supported by theoretical calculations. The conjoint of the electronic spectra and magnetic susceptibility measurements suggests plausible octahedral geometry for the cobalt(II) complexes while the copper(II) complexes adopt a square planar geometry. The stereochemistry of the modeled structures calculated by semi-empirical (PM3) and density functional theory (DFT) methods are also consistent with those experimentally deduced.

Design, synthesis and glucose uptake activity of some novel glitazones

Herein, we report a library consisting of some novel glitazones containing thiazolidinedione and its bioisosteres, rhodanine and oxadiazolidine ring structures as their basic scaffold for their antidiabetic activity. Twelve novel glitazones with diverse chemical structures were designed and synthesized by adopting appropriate synthetic schemes and analyzed. Later, subjected to in vitro glucose uptake assay in the absence and presence of insulin to confirm their antidiabetic activity using rat hemi-diaphragm. The titled compounds exhibited glucose uptake activity ranging weak to significant activity. Compounds 4, 5, 9, 11, 15, 16, 19 and 20 showed considerable glucose uptake activity apart from rosiglitazone, a standard drug. Compound 16 happens to be the candidate compound from this study to investigate further. The illustration about their design, synthesis, analysis and glucose uptake activity is reported here along with the in vitro and in silico study based structure-activity relationships.