53606-32-9

Upstream product

• 1071065-59-2 2-[(propan-2-yl)sulfanyl]benzyl alcohol 
• 75-33-2 2-propanethiol 
• 446-52-6 2-Fluorobenzaldehyde 
• 4521-31-7 o-hydroxymethyl thiophenol 
• 41394-95-0 2-isopropylmercaptobenzoic acid 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 900174-23-4 (E)-methyl 4-(2-(isopropylthio)benzylideneamino)butanoate 
• 1075220-34-6 2-isopropylsulphinylbenzaldehyde 
• 918811-07-1 tert-Butyl 3-(2-(isopropylthio)phenyl)acrylate 
• 1383610-96-5 (1R,2R)-N,N'-bis(2-(isopropylthio)benzylidene)-1,2-cyclohexanediamine 
• 1383610-78-3 N,N'-bis(2-(isopropylthio)benzylidene)-1,2-ethanediamine 
• 713131-98-7 (2E)-N-(4-hydroxycyclohexyl)-3-[2-(isopropylthio)phenyl]acrylamide 
• 1011534-95-4 1-(isopropylsulfanyl)-2-vinylbenzene 

Relevant academic research and scientific papers

SULFUR CHELATED RUTHENIUM COMPOUNDS USEFUL AS OLEFIN METATHESIS CATALYSTS

Sulfur chelated ruthenium compounds represented by the following formula: wherein M indicates the ruthenium metal bound to a benzylidene carbon; R represents C1-C7 alkyl group or optionally substituted aryl; X1 and X2 each independently represent halogen; Y1 and Y2 each independently denote unsubstituted or alkyl-substituted phenyl; and Z independently represents hydrogen, electron withdrawing or electron donating substituent, with m being an integer from 1 to 4, and processes and compositions related thereto.

Asymmetric hydrogenation of ketones with H2 and ruthenium catalysts containing chiral tetradentate S2N2 ligands

Getting more for less: In the presence of H2 and a base, air- and moisture-tolerant RuII complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 106:1. The reactions tolerate scale-up and can be carried out with almost no solvent. A base-free method is available for base-sensitive substrates. Copyright

HYDROGENATION OF ESTERS OR CARBONYL GROUPS WITH TETRADENTATE AMINO/IMINO-THIOETHER BASED RUTHENIUM COMPLEXES

The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of specific ruthenium catalysts, or pre-catalysts, in hydrogenation processes for the reduction of ketones and/or aldehydes into the corresponding alcohol respectively. Said catalysts are ruthenium complexes comprising a tetradentate ligand (L4) coordinating the ruthenium with: two nitrogen atoms, each in the form of a primary or secondary amine (i.e. a NH2 or NH group) or N-alkyl imine functional groups (i.e. a C═N group), and two sulfur atoms, each in the form of thioether functional groups.

Sulfur chelated ruthenium compounds useful as olefin metathesis catalysts

Sulfur chelated ruthenium compounds and methods and compositions involving the same. A method may relate to subjecting an olefin to a metathesis reaction in the presence of a sulfur chelated ruthenium compound. A composition may relate to an olefin starting material dissolved in an organic solvent together with a sulfur chelated ruthenium compound.

Latent sulfur chelated ruthenium catalysts: Steric acceleration effects on olefin metathesis

A series of sulfur chelated dormant ruthenium olefin metathesis catalysts is presented. The catalysts prepared were shown to possess the uncommon cis-dichloro arrangement and were mostly inactive at room temperature. By systematically modifying the size of the substituent groups at the chelating sulfur atom, catalyst activity at different temperatures was significantly affected; more bulky substituents fomented activity at lower temperatures. The catalysts were also shown to be stable in solution and retained their catalytic activity even after being exposed to air for two weeks.

SULPHUR-CONTAINING METATHESIS CATALYSTS

The present invention relates to novel transition metal complexes of the formula (I) to a process for preparing these transition metal complexes and to the use of the transition metal complexes as catalysts in metathesis reactions.

Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants

The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

Synthesis, characterization, and X-ray structural analysis of some half-sandwich ruthenium(II) arene complexes with new N,S-donor Schiff base ligands

A series of cationic, half-sandwich ruthenium complexes with the general formula [(η6-arene)RuCl(R1S-C6H4-2-CH{double bond, long}NR2)]+ (arene = p-cymene or hexamethylbenzene; R1

PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS

The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

A concise synthesis of ortho-substituted aryl-acrylamides - Potent activators of soluble guanylyl cyclase

Horner-Emmons reaction of phosphonate amides with aldehydes leads to generation of o-substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure-activity relationships (SAR) for soluble guanylyl cyclase (sGC)