53614-69-0Relevant academic research and scientific papers
Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia
Dahl, Russell,Bravo, Yalda,Sharma, Vandana,Ichikawa, Mie,Dhanya, Raveendra-Panickar,Hedrick, Michael,Brown, Brock,Rascon, Justin,Vicchiarelli, Michael,Mangravita-Novo, Arianna,Yang, Li,Stonich, Derek,Su, Ying,Smith, Layton H.,Sergienko, Eduard,Freeze, Hudson H.,Cosford, Nicholas D. P.
, p. 3661 - 3668 (2011)
We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes wit
