53621-85-5Relevant academic research and scientific papers
The formation of α-amino- and α-hydroxy-alkanephosphonic acids in the reactions of phosphite esters with aldehydes and alkyl carbamates
Hudson, Harry R.,Ismail, Fatima,Pianka, Max,Wan, Chi-Wai
, p. 245 - 257 (2000)
The preparation of α-aminoalkanephosphonic acids from triphenyl phosphite, an aldehyde, and ethyl or benzyl carbamate in glacial acetic acid, followed by hydrolysis, is accompanied by the formation of the corresponding α-hydroxyphosphonic acid. Reaction in toluene, using boron trifluoride-etherate as catalyst, affords an alternative preparative procedure but does not prevent the formation of α-hydroxyphosphonic acid. 31P nmr reveals the presence of numerous intermediates. The reactions are discussed.
