53627-11-5

Usage

Uses

Used in Pharmaceutical Industry:
(2-Chloroethyl)sulfaMoyl Chloride is used as a reagent for the synthesis of sulfonamides, which are important due to their pharmaceutical applications. It facilitates the formation of these compounds by reacting readily with amines.
Used in Agrochemical Production:
(2-Chloroethyl)sulfaMoyl Chloride is used as an intermediate in the production of various agrochemicals, highlighting its importance in the chemical industry and its contribution to agricultural solutions.
Used in Organic Synthesis:
(2-Chloroethyl)sulfaMoyl Chloride is used as a reactant in the synthesis of other sulfur-containing compounds, expanding its utility beyond the pharmaceutical and agrochemical sectors into broader organic chemistry applications.

Upstream product

• 870-24-6 2-chloroethanamine hydrochloride 

Downstream Products

• 57836-37-0 (2-Chloro-ethyl)-sulfamic acid [(2,6-diethyl-phenyl)-methoxymethyl-carbamoyl]-methyl ester 
• 182925-65-1 N-(2-chloroethyl)-N'-benzylsulfamide 

Relevant academic research and scientific papers

NOVEL INHIBITORS

The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic heteroaryl, which may independently substituted by alkyl or amino; B is selected from alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl and alkylene, wherein said groups may independently be substituted by alkyl; D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted; and E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted. The compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N- terminal glutamate residues into pyroglutamic acid under liberation of water.

VIRAL POLYMERASE INHIBITORS

The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, solvates, hydrates, racemates, enantiomers or isomers thereof, processes for their preparation and their use in the treatment of Flaviviridae viral infections such as Hepatitis C virus (HCV) infections: (I)

Heterocyclic antiviral compounds

Compounds having the formula I wherein R1, R2, R3, R4, R5 and X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV

Synthesis of N-substituted 1,2,5-thiadiazolidine and 1,2,6-thiadiazinane 1,1-dioxides from primary amines

Alkyl and aryl N-substituted 1,2,5-thiadiazolidine and 1,2,6-thiadiazinane 1,1-dioxides 6 were synthesized in good yields from the reaction of sulfuryl chloride with 2-chloroethylamine or 3-chloropropylamine hydrochlorides, respectively, followed by treatment with a primary amine and triethylamine, and ring closure with K2CO3 in DMSO.