53628-96-9Relevant academic research and scientific papers
Synthesis of 9-biarylfluorenes by one-pot, three-step reactions of N-tosylhydrazones, p-bromobenzeneboronic acid, and arylboronic acids
He, Jing,Zhang, Jie,Dai, Bin,Liu, Ping
, p. 268 - 273 (2019)
A one-pot, three-step reaction of N-tosylhydrazones, p-bromobenzeneboronic acid, and arylboronic acids is established for the synthesis of 9-biarylfluorenes. Sequential formation of Csp3–Csp2 bond and Csp2–Csp2
A simple and efficient synthesis of 9-arylfluorenes via metal-free reductive coupling of arylboronic acids and N-tosylhydrazones in situ
Shen, Xu,Gu, Ningning,Liu, Ping,Ma, Xiaowei,Xie, Jianwei,Liu, Yan,He, Lin,Dai, Bin
, p. 63726 - 63731 (2015/08/11)
A general, yet efficient synthesis method of 9-arylfluorenes via metal-free reductive coupling of N-tosylhydrazones and arylboronic acids has been developed. This methodology is realized by a one-pot protocol in two steps involving the preparation of N-tosylhydrazones by reacting tosylhydrazide with 9-fluorenone derivatives, followed by the reductive coupling of arylboronic acid in the presence of potassium carbonate to afford various 9-arylfluorenes analogues in moderate to excellent yields. Importantly, the catalytic system presented here enables the use of easily accessible starting materials and can be employed on a wide variety of substrates with good functional group tolerance. This protocol could also be particularly useful for the synthesis of 9-fluorenyl-substituted carbazolyl compounds.
