5363-32-6

Basic information

• Product Name: 2-(Isopropylamino)benzamide
• Synonyms: 2-(Isopropylamino)benzamide;o-(Isopropylamino)benzamide
• CAS NO: 5363-32-6
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.231
• Mol File: 5363-32-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 335.1°Cat760mmHg
• Flash Point: 156.4°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.000123mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 2-(Isopropylamino)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Isopropylamino)benzamide(5363-32-6)
• EPA Substance Registry System: 2-(Isopropylamino)benzamide(5363-32-6)

Safety Data

• Hazardous Substances Data: 5363-32-6(Hazardous Substances Data)

Usage

Structure

Benzene ring with an amino group and an isopropyl group attached to the second carbon atom

Type of compound

Amide derivative of 2-aminobenzamide

Usage

Synthesis of pharmaceuticals and agrochemicals

Potential applications

Treatment of various diseases, including cancer and neurological disorders

Role

Inhibitor of enzyme activity in drug discovery and development

InChI:InChI=1/C10H14N2O/c1-7(2)12-9-6-4-3-5-8(9)10(11)13/h3-7,12H,1-2H3,(H2,11,13)

Upstream product

• 57384-39-1 1-isopropyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 75-29-6 isopropyl chloride 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 81822-13-1 1-Isopropyl-2-p-tolyl-1H-quinazolin-4-one 
• 95216-53-8 1-Isopropyl-2-(2-methoxy-phenyl)-1H-quinazolin-4-one 
• 95216-52-7 2-(2-chlorophenyl)-2,3-dihydro-1-isopropyl-4(1H)-quinazolinone 
• 81822-08-4 2-(2-Bromo-phenyl)-1-isopropyl-1H-quinazolin-4-one 
• 95216-55-0 2-(4-aminophenyl)-1-isopropyl-4(1H)-quinazolinone 
• 35681-40-4 1,3-dihydro-1-(1-methylethyl)-2H-benzimidazol-2-one 
• 145429-39-6 o-(isopropylamino)benzylamine 
• 81822-16-4 2-(4-Bromo-phenyl)-1-isopropyl-1H-quinazolin-4-one 
• 95216-76-5 2-(2-Bromo-phenyl)-1-isopropyl-2,3-dihydro-1H-quinazolin-4-one 
• 81822-14-2 2-(3,4-Dichloro-phenyl)-1-isopropyl-1H-quinazolin-4-one 
• 95216-54-9 1-Isopropyl-2-(4-nitro-phenyl)-1H-quinazolin-4-one 
• 81822-11-9 2-(4-Chloro-phenyl)-1-isopropyl-1H-quinazolin-4-one 
• 81822-02-8 1-isopropyl-2-phenyl-4(1H)-quinazolinone 
• 81822-09-5 2-(2-Chloro-phenyl)-1-isopropyl-1H-quinazolin-4-one 

Relevant articles and documents

Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives

A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most of the compounds were obtained by the cyclization of the appropriately substituted anthranilamides with acid chlorides, followed by further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, and 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency and the presence of a halogen atom is preferred for activity. Adrenalectomy does not affect the antiinflammatory test results. The best result taking into account both efficacy and side effects was displayed by 1-isoproyl-(2-fluorophenyl)-4(1H)-quinazolinone.