53630-76-5Relevant academic research and scientific papers
C(sp3)-H Azidation Reaction: A Protocol for Preparation of Aminals
Dong, Jianyang,Xia, Qing,Yan, Changcun,Song, Hongjian,Liu, Yuxiu,Wang, Qingmin
, p. 4516 - 4524 (2018)
We report a protocol for the synthesis of N,N- and N,O-aminals via direct azidation of sp3 C-H bonds of substrates with an α-nitrogen or α-oxygen atom. A broad range of tetrahydroisoquinolines, tetrahydro-β-carbolines, and cyclic benzyl ethers gave high yields under mild conditions. The protocol could be carried out on a gram scale without a decrease in the yield, and the aminal products could be readily transformed into complex aminals.
