53643-48-4 Usage
Originator
Eldisine,Lilly ,France,1980
Uses
Antineoplastic.
Manufacturing Process
About 10 g of VLB (vincaleucoblastine or simply vinblastine) sulfate were
converted by standard procedures to VLB free base. The free base, obtained
as a residue after evaporation of the dried ethereal solvent, was dissolved in
about 200 ml of anhydrous methanol. Anhydrous liquid ammonia (300 ml)
was added, and the reaction mixture sealed and maintained at about 100°C
for 60 hours. The reaction vessel was opened, and the contents removed and
evaporated to dryness in vacuo. The resulting residue, containing 4-desacetyI
VLB C-3 carboxamide, as shown by thin layer chromatography, were combined
and the solvent evaporated therefrom in vacuo, yielding asa residue purified
4-desacetyl VLB C-3 carboxamide free base. The NMR and IR spectra of the
solid free base confirmed the structure indicated. The free base showed a
band in the infrared at 1,687 cm -l , characteristic of the amide function. The
molecular weight of the free base determined by mass spectroscopy was 753
which is in agreement with theoretical value calculated for C 43 H 55 N 5 O 7 .
Brand name
Eldisine (Lilly).
Therapeutic Function
Antineoplastic
Check Digit Verification of cas no
The CAS Registry Mumber 53643-48-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,6,4 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 53643-48:
(7*5)+(6*3)+(5*6)+(4*4)+(3*3)+(2*4)+(1*8)=124
124 % 10 = 4
So 53643-48-4 is a valid CAS Registry Number.
InChI:InChI=1/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,27,34-36,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,27?,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1
