53645-33-3Relevant academic research and scientific papers
PROTONATION AND SULFONATION OF GRAMINE IN STRONG SULFURIC ACID
Fatum, Tine M.,Anthoni, Uffe,Christophersen, Carsten,Nielsen, Per H.
, p. 1619 - 1626 (2007/10/02)
Gramine (3-dimethylaminomethylindole) when treated with concentrated sulfuric acid at room temperature, after protonation at the dimethylamino group and at position 3, was sulfonated at the aromatic positions.Initial sulfonation in either the 5- or 6-position was succeeded by introduction of a second sulfonic acid group giving a mixture of gramine-4,6-disulfonic acid, gramine-5,7-disulfonic acid and gramine-2,6- or gramine-2,5-disulfonic acid.
