53645-94-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-Methyl-1,3,4-thiadiazole is used as a key intermediate in the synthesis of drugs for a range of medical applications. Its reactivity with other chemicals allows for the creation of active pharmaceutical ingredients, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-5-Methyl-1,3,4-thiadiazole is utilized as a building block in the production of various agrochemicals. Its role in the synthesis of bioactive compounds makes it a valuable component in the development of pesticides and other agricultural chemicals.
Due to its potential to react with other chemicals and its use in the production of active pharmaceutical ingredients, 2-Chloro-5-Methyl-1,3,4-thiadiazole should be handled with caution and in accordance with appropriate safety measures to ensure the safety of both individuals and the environment.

Upstream product

• 108-33-8 5-methyl-1,3,4-thiadiazol-2-amine 

Downstream Products

• 98025-62-8 2-hydrazino-5-methyl-1,3,4-thiadiazole 
• 103344-16-7 2-methyl-6-phenyl-8H-<1,3,4>thiadiazolo<3,2-a>thieno<2,3-d>pyrimidin-8-one 

Relevant academic research and scientific papers

Deaminative chlorination of aminoheterocycles

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

Mesoionic pyrido[1,2-a]pyrimidinones: A novel class of insecticides inhibiting nicotinic acetylcholine receptors

A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species, particularly hemiptera and lepidoptera. Mode-of-action studies showed that they act on nicotinic acetylcholine receptors (nAChRs) primarily as inhibitors. Here we report the discovery, evolution, and preparation of this class of chemistry. Our efforts in structure–activity relationship elucidation and biological activity evaluation are also presented.