53653-22-8

Usage

Uses

Used in Research Applications:
6-Nitro-2-hydroxynaphthalene-1-carboxaldehyde is used as a research chemical for its fluorescent properties, which can be utilized in various experimental procedures. 6-NITRO-2-HYDROXYNAPHTHALENE-1-CARBOXALDEHYDE's unique structure allows for its use in studying chemical reactions and interactions.
Used in Chemical Reactions:
6-Nitro-2-hydroxynaphthalene-1-carboxaldehyde is used as a reactant in various chemical reactions due to its diverse functional groups. These groups enable the compound to participate in a wide range of reactions, making it a valuable tool in the synthesis of other compounds.
Used in Pharmaceutical Research:
While more research is needed, 6-Nitro-2-hydroxynaphthalene-1-carboxaldehyde has the potential for use in pharmaceutical applications. Its unique structure and functional groups may contribute to the development of new drugs or drug delivery systems.
Used in Industrial Applications:
6-Nitro-2-hydroxynaphthalene-1-carboxaldehyde may also find use in industrial applications, particularly in the synthesis of dyes, pigments, or other specialty chemicals. Its fluorescent properties and reactivity could be harnessed for the production of novel materials with specific properties.

Upstream product

• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 135-19-3 β-naphthol 

Downstream Products

• 60168-22-1 1'-hexadecyl-3',3'-dimethyl-8-nitro-1',3'-dihydro-spiro[benzo[f]chromene-3,2'-indole] 
• 4963-43-3 1',3',3'-trimethyl-8-nitrospiro[benzo[f]chromene-3,2'-indoline] 
• 144723-41-1 1',3',3'-trimethyl-5',8-dinitrospiro[benzo[f]chromene-3,2'-indoline] 
• 60168-23-2 1,3-dimethyl-3-hexadecyl-8'-nitro(spiroindoline-2,3'-(3H)-naphtho(2,1-b)pyran) 

Relevant academic research and scientific papers

Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease

A novel series of boron-containing compounds were designed, synthesized and evaluated as multi-target-directed ligands against Alzheimer's disease. The biological activity results demonstrated that these compounds possessed a significant ability to inhibit self-induced Aβ aggregation (20.5-82.8%, 20 μM) and to act as potential antioxidants (oxygen radical absorbance capacity assay using fluorescein (ORAC-FL) values of 2.70-5.87). In particular, compound 17h is a potential lead compound for AD therapy (IC50 = 3.41 μM for self-induced Aβ aggregation; ORAC-FL value = 4.55). Compound 17h also functions as a metal chelator. These results indicated that boron-containing compounds could be new structural scaffolds for the treatment of AD.

Comparative Evaluation of Substituent Effect on the Photochromic Properties of Spiropyrans and Spirooxazines

Spiropyrans and spirooxazines represent an important class of photochromic compounds with a wide variety of applications. In order to effectively utilize and design these photoswitches it is desirable to understand how the substituents affect photochromic properties, and how the different structural motifs compare under identical conditions. In this work a small library of photoswitches was synthesized in order to comparatively evaluate the effect of substituent modifications and structure on photochromism. The library was designed to modify positions that were believed to have the greatest effect on C-O bond lability and therefore the photochromic properties. Herein we report a comparative analysis of the UV and visible light responses of 30 spiropyrans, spiroindolinonaphthopyrans, and spirooxazines. The influence of gadolinium(III) binding was also investigated on the library of compounds to determine its effect on photoswitching. Both assays demonstrated different trends in substituent and structural requirements for optimal photochromism.

Oxidation of 1-acyl-2-naphthol oximes: peri- and o-cyclisation and spiro cyclodimerisation of naphthoquinone nitrosomethide intermediates

The oxidation of 2-hydroxynaphthaldehyde oxime with lead(IV) acetate (LTA) gave a mixture of naphtho[1,8-de][1,2]oxazine and a spiro dimer. LTA oxidation of 6-bromo (or nitro)-2-hydroxynaphthaldehyde oximes provided only spiro dimers. Similar treatment of (2-hydroxy-1-naphthyl)keto oximes with LTA gave naphtho[1,8-de][1,2]oxazines and benzo[cd]indol-3(1H)-ones. Low temperature oxidation of 1-(2-hydroxy-1-naphthyl)propan-1-one oxime furnished 2-ethylbenzo[cd]indol-3(1H)-one and 1-ethylnaphtho[1,2-d]isoxazole-2-oxide. peri- and o-Naphthoquinone nitrosomethides are invoked as intermediates that undergo peri- and o-cyclisation and intermolecular cyclodimerisation.