53653-60-4Relevant academic research and scientific papers
Promotion of mitochondrial biogenesis by synthetic 1,2- or 1,3-digallates through activation of an energy sensing network
Lee, Taegum,Kim, Mi Kyoung,Chong, Youhoon
, p. 407 - 411 (2022/01/08)
Based on the observations suggesting that a digallate functionality might serve as a novel scaffold for inducers of mitochondrial biogenesis, we prepared a series of digallates and evaluated their activity in an in vitro model widely used in PD research (
Double-gallic acid ester derivative in the preparation of the use in the medicament for treating hyperuricemia
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, (2017/08/25)
The invention discloses application of a digallate derivative which has a formula (I) and a pharmaceutically acceptable salt thereof to preparation of a medicine for treating hyperuricemia. The digallate derivative has a strong effect of inhibiting xanthi
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
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, (2015/09/22)
The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
New synthetic inhibitors of fatty acid synthase with anticancer activity
Turrado, Carlos,Puig, Teresa,García-Cárceles, Javier,Artola, Marta,Benhamú, Bellinda,Ortega-Gutiérrez, Silvia,Relat, Joana,Oliveras, Gloria,Blancafort, Adriana,Haro, Diego,Marrero, Pedro F.,Colomer, Ramón,López-Rodríguez, María L.
experimental part, p. 5013 - 5023 (2012/07/30)
Fatty acid synthase (FASN) is a lipogenic enzyme that is highly expressed in different human cancers. Here we report the development of a new series of polyphenolic compounds 5-30 that have been evaluated for their cytotoxic capacity in SK-Br3 cells, a hu
Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism
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, (2009/01/23)
The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate
Dodo, Kosuke,Minato, Taro,Hashimoto, Yuichi
experimental part, p. 190 - 194 (2009/11/30)
Green tea and (-)-epigallocatechin gallate (EGCG: one of main components of green tea) are well known to have preventive activities against human cancers. Previously, using a galloyl group as a core structure derived from EGCG, we developed alkyl gallate and gallamide derivatives, which showed strong antiproliferative activity towards human leukemia HL-60 cells by inducing apoptosis. Here, as a further structural development study, we planned to introduce an additional galloyl group into alkyl gallates and gallamides. According to this strategy, various bisgallate and bisgallamide derivatives were synthesized and tested for antiproliferative activity towards HL-60 cells. In gallamide derivatives having a short alkyl chain, the additional galloyl group enhanced the antiproliferative activity. In contrast, in the gallate derivatives, the additional galloyl group had no effect on the antiproliferative activity.
