53661-28-2Relevant academic research and scientific papers
Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase
Van Linden, Oscar P.J.,Farenc, Carine,Zoutman, Willem H.,Hameetman, Liesbeth,Wijtmans, Maikel,Leurs, Rob,Tensen, Cornelis P.,Siegal, Gregg,De Esch, Iwan J.P.
, p. 493 - 500 (2012/03/11)
The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially
Reaction of Methylene Active Nitriles and Cyanamide with Acylated Enamines
Gewald, K.,Schaefer, H.,Bellmann, P.
, p. 933 - 941 (2007/10/02)
The addition products from enamines onto isocyanates and isothiocyanates, i.e. substituted β-aminoacrylo amides 1 and thioamides 2, react with malononitrile to yield the 6-amino-1-aryl-5-cyano-pyridin-2-ones 3 and -thiones 4 among them 5,6,7,8-tetrahydroi
Amide-Catalysed Isomerisation of 5,6-Dihydroisoquinolines: a Novel Synthesis of 1,2-Dihydroisoquinolines
Kasturi, Tirumalai Rangachar,Krishnan, Lalitha,Prasad, Ramanujam Srinivasa
, p. 63 - 68 (2007/10/02)
Knoevenagel condensation of 2-acylcyclohexanones or 2-ethoxycarbonylcyclohexanone with either cyanoacetamide or malononitrile followed by silver salt alkylation gave the 5,6,7,8-tetrahydroisoquinolines (3a-i).Chromic acid oxidation of the 5,6,7,8-tetrahyd
