53662-94-5

Basic information

• Product Name: 5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone
• Synonyms: 5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone
• CAS NO: 53662-94-5
• Molecular Formula: C15H24O2
• Molecular Weight: 236.34986
• Mol File: 53662-94-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone(53662-94-5)
• EPA Substance Registry System: 5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone(53662-94-5)

Safety Data

• Hazardous Substances Data: 53662-94-5(Hazardous Substances Data)

Upstream product

• 878-47-7 (4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one 
• 115-11-7 isobutene 
• 50302-16-4 (4aS,5S)-5-Hydroxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 

Downstream Products

• 69268-96-8 (3R,4aS,5S)-1,3-Bis-benzenesulfonylmethyl-5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 
• 61930-70-9 1β-tert.-butoxy-8aβ-methyl-5-(phenylsulfonylmethyl)-1,2,3,4,6,7,8,8a-octahydronaphthalene-6-one 
• 65137-51-1 (1R,4aS,5S,8aR)-5-tert-Butoxy-1-[2-(3-methoxy-phenyl)-ethyl]-4a-methyl-octahydro-naphthalen-2-one 
• 65137-50-0 (1S,4aS,5S,8aR)-5-tert-Butoxy-1-[2-(3-methoxy-phenyl)-ethyl]-4a-methyl-octahydro-naphthalen-2-one 
• 65083-12-7 17aβ-(t-Butoxy)-3-methoxy-D-homo-9,10-secooestra-1,3,5(10),8(14)-tetraen-6,9-dion 

Relevant articles and documents

Improved Preparation of Enantiomerically Pure (+)-(4aS,5S)-5-tert-Butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone

(+)-(4aS,5S)-5-tert-Butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone (6) is a key intermediate in the synthesis of D-homosteroids.Compound 6 was prepared in a five-step sequence via the Wieland-Miescher ketone 4, following the Eder-Sauer-Wiechert-Hajos procedure involving asymmetric intramolecular aldol condensation of the prochiral trione 2 using catalytic amounts of L-proline, with an ee of 63-70percent.Enantiomerically pure 6 was obtained by recrystallization from petroleum ether.

Two-carbon intercalation. 4-cyclooctenones by tandem application of double tebbe and claisen reactions

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