536709-95-2

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 53558-04-6 5-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-methyl-isoxazol-4-ylamine 

Downstream Products

• 536710-10-8 3-{5-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-methyl-isoxazol-4-yl}-2-[(Z)-phenylimino]-thiazolidin-4-one 
• 756483-14-4 3-{5-[(E)-2-(4-Chloro-phenyl)-vinyl]-3-methyl-isoxazol-4-yl}-2-[(Z)-phenylimino]-2,3-dihydro-thiazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of 5-methyl-2-[2-methyl/phenylimino-3-(3-methyl-5-styryl- isoxazol-4-yl)-2,3-dihydro-thiazole-4-carbonyl]-2,4-dihydro-pyrazol-3-ones, 1,3,4-oxadiazoles and 4-oxo-thiazolin-5-ylidene-acetic acid methyl esters

Isoxazolyl thioureas 2 on reaction with ethyl bromopyruvate give methyl/phenyl [4-carboethoxy-3-(3-methyl-5-styryl-isoxazol-4-yl)3H-thiazol-2- ylidene]amines 3, which on treatment with hydrazine hydrate affords corresponding acid hydrazides 4. The acid hy

Synthesis and bioactivity of isoxazolyl thiazoles, isoxazolyl thiazolyl chromen-2-ones, isoxazolyl thiazinanes and isoxazolyl thiazolidinones

A series of substituted methyl/phenyl-[4-methyl/carboethoxy/3-(3-methyl-5-styryl-isoxazol-4-yl) -3H-thiazol-2-ylidene]amines 3,substituted-3-[2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)-2, 3-dihydrothiazol-4-yl]-chromen-2-ones 4, substituted 5-methyl-2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl) thiazolidin-4-ones 5 and substituted methyl/phenyl-[3-(3-methyl-5-styryl-isoxazol-4-yl)-[1,3]-thiazinan-2-ylidene] amines 6 have been synthesized by the reaction of substituted 1-methyl/phenyl-3-(3-methyl-5-styryl-isoxazol-4-yl)thioureas 2 with chloroacetone or ethyl bromopyruvate, 3-(ω-bromoacetyl)coumarin, ethyl 2-bromopropionate and 1,3-dibromo-propane, respectively. All the compounds have been evaluated for their antimicrobial activity.

Synthesis of isoxazolylpyrazolo[3,4-d]thiazoles and isoxazolylthiazoles and their antibacterial and antifungal activity

Substituted methyl/phenyl-[3-(3-methyl-S-styryl-isoxazol-4-yl)-4-phenyl-3H- thiazol-2-ylidene]-amines 6, substituted-methyl/phenyl-[3-(3-methyl-S-styryl- isoxazol-4-yl)-thiazolidin-2-ylidene]-amines 7 and substituted 2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)-thiazolidin-4-ones 3, have been synthesized by the reaction of substituted 1-methyl/phenyl-3-(3- methyl-5-styryl-isoxazol-4-yl)-thioureas 2 with phenacyl bromide, 1,2-dichloroethane and chloroacetic acid respectively. Condensation of 3 with aromatic aldehydes or interaction of 2 with ethyl chloroacetate and aromatic aldehydes in the presence of pyridine and piperidine in a single step, gives substituted-5-arylidene-2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl) -thiazolidin-4-ones 4, which are then cyclised to substituted [2-(2,4-dinitrophenyl)-6-(3-methyl-5-styryl-isoxazol-4yl)-3-aryl-2,3,3a, 6-tetrahydro-pyrazolo[3,4-d]thiazol-5-ylidene]-methyl/phenyl-amines 5 by reaction with 2,4-dinitrophenyl hydrazine in the presence of anhyd. sodium acetate. All the compounds have been evaluated for their antibacterial and antifungal activity.

Synthesis of isoxazolyl pyrimidine diones & isoxazolyl thiazolidinones

A series of 3-phenyl/methyl-1-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl) -2,3-dihydro-2-thioxo-4,6(1H, 5H) pyrimidinediones 3 have been prepared from 1-phenyl/methyl-4-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)thioureas 2 by heating with malonic acid in acetyl chloride. Compounds 2 are obtained by interaction of 4-amino-3 -methyl-5-styryl/substituted styryl isoxazole 1 with phenyl and methyl isothiocyanates. The thioureas 2 when refluxed with chloroacetic acid and sodium acetate in absolute alcohol afford the corresponding 3-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)-2-phenyl/methyl imino-4-thiazolidinones 4. All the compounds have been evaluated for their biological activity.