536710-14-2Relevant academic research and scientific papers
Synthesis of isoxazolylpyrazolo[3,4-d]thiazoles and isoxazolylthiazoles and their antibacterial and antifungal activity
Rajanarendar,Afzal,Karunakar
, p. 168 - 173 (2007/10/03)
Substituted methyl/phenyl-[3-(3-methyl-S-styryl-isoxazol-4-yl)-4-phenyl-3H- thiazol-2-ylidene]-amines 6, substituted-methyl/phenyl-[3-(3-methyl-S-styryl- isoxazol-4-yl)-thiazolidin-2-ylidene]-amines 7 and substituted 2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)-thiazolidin-4-ones 3, have been synthesized by the reaction of substituted 1-methyl/phenyl-3-(3- methyl-5-styryl-isoxazol-4-yl)-thioureas 2 with phenacyl bromide, 1,2-dichloroethane and chloroacetic acid respectively. Condensation of 3 with aromatic aldehydes or interaction of 2 with ethyl chloroacetate and aromatic aldehydes in the presence of pyridine and piperidine in a single step, gives substituted-5-arylidene-2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl) -thiazolidin-4-ones 4, which are then cyclised to substituted [2-(2,4-dinitrophenyl)-6-(3-methyl-5-styryl-isoxazol-4yl)-3-aryl-2,3,3a, 6-tetrahydro-pyrazolo[3,4-d]thiazol-5-ylidene]-methyl/phenyl-amines 5 by reaction with 2,4-dinitrophenyl hydrazine in the presence of anhyd. sodium acetate. All the compounds have been evaluated for their antibacterial and antifungal activity.
Synthesis of isoxazolyl pyrimidine diones & isoxazolyl thiazolidinones
Rajanarendar,Afzal,Karunakar
, p. 353 - 357 (2007/10/03)
A series of 3-phenyl/methyl-1-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl) -2,3-dihydro-2-thioxo-4,6(1H, 5H) pyrimidinediones 3 have been prepared from 1-phenyl/methyl-4-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)thioureas 2 by heating with malonic acid in acetyl chloride. Compounds 2 are obtained by interaction of 4-amino-3 -methyl-5-styryl/substituted styryl isoxazole 1 with phenyl and methyl isothiocyanates. The thioureas 2 when refluxed with chloroacetic acid and sodium acetate in absolute alcohol afford the corresponding 3-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)-2-phenyl/methyl imino-4-thiazolidinones 4. All the compounds have been evaluated for their biological activity.
