536745-00-3

Upstream product

• 1822-00-0 trimethylsilylmethyllithium 
• 536744-99-7 1-[4-[2-(dimethylphenylsilanyl)ethyl]-5-hydroxymethyl-1-(toluene-4-sulfonyl)pyrrolidin-3-yl]ethanone 
• 536744-95-3 1-[5-benzyloxymethyl-1-(toluene-4-sulfonyl)-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl]-ethanone 
• 536745-03-6 1-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-pent-3-yn-2-ol 
• 536744-97-5 1-[5-benzyloxymethyl-4-[2-(dimethylphenylsilanyl)ethyl]-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]ethanone 
• 536744-94-2 N-1-[benzyloxymethyl-4-(tertbutyldimethylsilanoxy)but-2-ynyl]-N-but-2-ynyl-4-methylbenzenesulfonamide 
• 536744-98-6 1-[4-[2-(dimethylphenylsilanyl)ethyl]-5-hydroxymethyl-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]ethanone 
• 536744-92-0 1-benzyloxy-5-(tert-butyldimethylsilanyloxy)pent-3-yn-2-ol 
• 536744-93-1 1-benzyloxy-5-(tert-butyldimethylsilanoxy)pent-3-yn-2-one 
• 286376-23-6 4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide 

Downstream Products

• 536745-01-4 2-[2-hydroxymethyl-4-isopropenyl-1-(toluene-4-sulfonyl)-pirrolidin-3-yl]-ethanol 
• 536745-04-7 3-carboxymethyl-4-isopropenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Ruthenium-catalyzed cycloisomerizations of diynols

A wide variety of diynols containing tertiary, secondary, and primary propargylic alcohols undergo a cycloisomerization reaction to form dienones and dienals in the presence of a catalytic amount of [CpRu(CH3CN) 3]PF6. The

Ruthenium-catalyzed alkyne-propargyl alcohol addition. An asymmetric total synthesis of (+)-alpha-kainic acid.

A novel route to the neuroexcitatory amino acid, kainic acid, is developed. The key concept derives from a ruthenium-catalyzed cycloisomerization of a tethered alkyne-propargyl alcohol to form a cyclic 2-vinyl-1-acyl compound. A single stereocenter introd