536754-44-6Relevant academic research and scientific papers
Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
Lovering, Frank,Kirincich, Steve,Wang, Weiheng,Combs, Kerry,Resnick, Lynn,Sabalski, Joan E.,Butera, John,Liu, Julie,Parris, Kevin,Telliez
experimental part, p. 3342 - 3351 (2009/09/08)
A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained and a structure based approach was followed to optimize potency and selectivity.
