53683-95-7Relevant academic research and scientific papers
Facile direct synthesis of acetylenedicarboxamides
Heyl, Dirk,Fessner, Wolf-Dieter
, p. 1463 - 1468 (2014/06/10)
A convenient, rapid and widely applicable one-pot procedure has been developed for the synthesis of acetylenedicarboxamides from various primary and secondary amines, including amino acid derivatives, protected carbohydrates, and fluorescent labels. By using DMTMM for amide coupling, acetylenedicarboxylic acid was directly converted into acetylenedicarboxamides in highly competitive overall yields (52-80%). Georg Thieme Verlag Stuttgart New York.
