53686-18-3Relevant academic research and scientific papers
Synthesis method of 1, 3-diaryl substituted tetrazolone inner salt
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Paragraph 0047-0051, (2021/03/31)
The invention provides a method for synthesizing 1, 3-diaryl substituted tetrazolone inner salt, which comprises the following steps of: a, reacting a diaryl semicarbazide reagent serving as a reaction raw material in a reaction solvent under the action of a catalyst and alkali to obtain the 1, 3-diaryl substituted tetrazolone inner salt, mixing 0.5 mmol of diarylaminourea with 10 mol% of palladium acetate serving as a catalyst, adding 1.0 mmol of potassium carbonate serving as alkali, putting the mixed solution into a solvent, controlling the reaction temperature to be 70-100 DEG C, and magnetically stirring for 2-4 hours; b, in the reaction process, TLC is used for monitoring the complete reaction, after the reaction is finished, the temperature is reduced to the room temperature, afterthe reaction is finished, a proper amount of water is added for quenching reaction treatment, then a proper amount of dichloromethane is added for extraction, anhydrous sodium sulfate is added for drying, the solvent is subjected to reduced-pressure spin-drying, and then pure 1, 3-diaryl substituted tetrazolone inner salt is obtained through column chromatography separation.
