53696-32-5Relevant academic research and scientific papers
Cyclization of cyanoethylated ketones as a route to 6-substituted indole derivatives
Bergman, Jan,Stensland, Birgitta
, p. 1 - 10 (2014/02/14)
δ-Cyanoketones are quickly cyclized with KOtBu to 3-aminocyclohex-2-enone derivatives, which in turn will give substituted indoles when treated with oxalyl chloride. Thus, 3-amino-6,6-dimethylcyclohex-2-enone gave 3-chloro-6,6-dimethyl-2,5,6,7-tetrahydroindole-2,5-dione, whose structure was corroborated by X-ray crystallography, whereas the corresponding molecule without the blocking gem-dimethyl groups, 3-aminocyclohex-2-enone, gave via hydrogen shifts 6-chloro-3-hydroxyoxindole.
A SIMPLE, CONVENIENT SYNTHESIS OF 4,4-DIMETHYL-1,3-CYCLOHEXANEDIONE
Maini, Prem Nath,Sammes, Michael P.
, p. 731 - 736 (2007/10/02)
Methyl propenoate and 3-methyl-2-butanone react together in xylene in the presence of sodium methoxide to give a high yield of the title compound.
