536977-34-1Relevant articles and documents
Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography
O'Brien, Alexander G.,Horvath, Zoltan,Levesque, Francois,Lee, Ju Weon,Seidel-Morgenstern, Andreas,Seeberger, Peter H.
, p. 7028 - 7030 (2012)
Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module (see scheme). Copyright