537003-63-7Relevant academic research and scientific papers
Synthesis and calcium modulatory activity of 3-alkyloxy-carbonyl-4- (disubstituted)aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives
Simsek, Rahime,Oeztuerk, Goekce S.,Vural, I. Mert,Guenduez, Miyase G.,Sarioglu, Yusuf,Safak, Cihat
, p. 55 - 60 (2008/09/21)
In this study, twelve hexahydroquinoline derivatives which are condensed analogs of the 1,4-DHP molecule were synthesized and evaluated for their calcium-antagonistic activity. The results indicated that all compounds and nifedipine produced concentration-dependent relaxation in rabbit gastric fundus smooth muscle strips. The relaxant effects of the compounds on the tissues were expressed as percentage of the precontraction using Ca2+. The maximum response (Emax) and pD2 values (the negative logarithm of the concentration for the half-maximal response (EC50)) were calculated. It is generally believed that introduction of a second electron-withdrawing substituent into the phenyl ring increases the mentioned activity. Methyl-2,7,7-trimethyl-4-(2-nitro-5-chlorophenyl)-5-oxo-1,4,5,6,7,8- hexahydroquinoline-3-carboxylate 2a has been found to be the most active compound in this serie.
