537036-78-5

Basic information

• Product Name: Benzonitrile, 2-(2-bromophenoxy)-
• CAS NO: 537036-78-5
• Molecular Formula: C13H8BrNO
• Molecular Weight: 274.117
• Mol File: 537036-78-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-(2-bromophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-(2-bromophenoxy)-(537036-78-5)
• EPA Substance Registry System: Benzonitrile, 2-(2-bromophenoxy)-(537036-78-5)

Safety Data

• Hazardous Substances Data: 537036-78-5(Hazardous Substances Data)

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 95-56-7 2-hydroxybromobenzene 

Downstream Products

• 90-47-1 xanth-9-one 
• 917477-33-9 2-(2-bromophenoxy)benzoic acid 
• 51412-72-7 dibenzo-[b,d]furan-4-carbonitrile 

Relevant articles and documents

Expedient Pd-Catalyzed α-Arylation towards Dibenzoxepinones: Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids

The general synthesis of diversely substituted dibenzoxepinones by a combined Pd-catalyzed α-arylation and SNAr strategy is reported and applied to the synthesis of Manske's ketone, a key intermediate en route to the total synthesis of cularine alkaloids. In the course of this work, an unanticipated ring contraction reaction to a xanthone was observed and serves as a caveat for the conditions of the widely used α-arylation reaction.

Formal Aniline Synthesis from Phenols through Deoxygenative N-Centered Radical Substitution

Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source. The applicability of this triethyl phosphite mediated O-atom transfer approach, which tolerates a range of steric and electronic demands to naturally occurring phenols and lignin models, has been demonstrated in this work to access the corresponding aniline derivatives.

One-pot Synthesis of Dibenzofurans via SNAr and Subsequent Ligand-free Palladium-catalyzed Intramolecular Aryl-aryl Cross-coupling Reactions under Microwave Irradiation

An efficient one-pot synthesis of dibenzofurans, via SNAr reaction of aryl halides and ortho-bromophenols in the presence of anhydrous K2CO 3 and subsequent ligand-free palladium-catalyzed intramolecular aryl-aryl cross-coupling cyclization under microwave irradiation, is described.