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53716-43-1

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  • [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]2-[1-(phenylmethyl)indazol-3-yl]oxyacetate

    Cas No: 53716-43-1

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53716-43-1 Usage

Originator

Versacort,Angelini,Italy,1978

Manufacturing Process

Hydrocortisone (25 g) and bendazac chloride (21 g) are suspended in anhydrous dioxane (250 ml). Pyridine (6 ml) is added and the solution is kept under stirring for 2 hours at room temperature. Pyridine hydrochloride which separates is filtered and the clear dioxane solution is added, under strong stirring, to a solution of sodium bicarbonate (20 g) in distilled water (2,500 ml). The colorless precipitate which is formed is filtered, washed with water and dried on a porous plate. The substance crystallizes from ethanol. Needles. MP 174°-176°C. Yield: 75%.

Therapeutic Function

Glucocorticoid

Safety Profile

An experimental teratogen. Whenheated to decomposition it emits toxic fumes of NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 53716-43-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,1 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 53716-43:
(7*5)+(6*3)+(5*7)+(4*1)+(3*6)+(2*4)+(1*3)=121
121 % 10 = 1
So 53716-43-1 is a valid CAS Registry Number.

53716-43-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Bendacort

1.2 Other means of identification

Product number -
Other names PREGN-4-ENE-3,20-DIONE,11,17-DIHYDROXY-21-[[2-[[1-(PHENYLMETHYL)-1H-INDAZOL-3-YL]OXY]ACETYL]OXY]-, (11B)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:53716-43-1 SDS

53716-43-1Downstream Products

53716-43-1Relevant articles and documents

Syntheses and antiinflammatory activities of the esters of antiphlogistically effective carboxylic acids with hydrocortisone

Laurent,Albring,Wendt

, p. 421 - 424 (2007/10/02)

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