53721-41-8

Basic information

• Product Name: bis(benzylamino)phenylphosphine oxide
• Synonyms: bis(benzylamino)phenylphosphine oxide
• CAS NO: 53721-41-8
• Molecular Weight: 336.373
• Mol File: 53721-41-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: bis(benzylamino)phenylphosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: bis(benzylamino)phenylphosphine oxide(53721-41-8)
• EPA Substance Registry System: bis(benzylamino)phenylphosphine oxide(53721-41-8)

Safety Data

• Hazardous Substances Data: 53721-41-8(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 352031-14-2 1,3-diphenylsulfonyl-2-oxo-2-phenyl-1,3,2-diazaphospholidine 
• 74518-37-9 1,3-Dibenzyl-2-oxo-2-phenyl-2λ⁵-[1,3,2]diazaphospholidine-4,5-dione 
• 824-72-6 P,P-dichlorophenylphosphine oxide 

Downstream Products

• 74518-37-9 1,3-Dibenzyl-2-oxo-2-phenyl-2λ⁵-[1,3,2]diazaphospholidine-4,5-dione 
• 170501-70-9 C₆₇H₇N 

Relevant articles and documents

Ultrasound-promoted, rapid and green synthesis of phosphonamide derivatives under catalyst and solvent-free conditions

We report a rapid, efficient, economic, environmentally benign, and easy to scale-up method for the synthesis of phosphonamide derivatives using ultrasound irradiation, under catalyst and solvent-free conditions starting from the corresponding amine and phenyl phosphonic dichloride. The reaction was achieved in excellent isolated yield in a short reaction time at room temperature. The structures of the synthesized compounds are confirmed by elemental analysis as well as by IR and 1H, 13C, 31P NMR spectroscopic data and mass spectrometry.

Intramolecular catalysis of aminolysis of phosphorus heterocycles incorporating an α-aminoamide moiety. III. Synthesis of 2-oxo or 2-thioxo 1,3-disulfonyl-1,3,2-diazaphospholidines and reactions with amines and alcohols

A series of 2-oxo or 2-thioxo 1,3-disulfonyl-1,3,2-diazaphospholidines 4 was prepared by condensation of phosphonyl dichlorides 2 with bis-N,N′-sulfonylethylenediamines 1 in pyridine. Complete aminolysis or alcoholysis of heterocycles 4 took place with regeneration of sulfonyldiamines 1. These reactions are very sensitive to steric hindrance, and hydrolysis is generally favoured over aminolysis. The results are discussed in terms of mechanisms of phosphorylation.

SYNTHESE DE TRIOXO-2,4,5-DIAZA-1,3-PHOSPHOLIDINES-2-TRISUBSTITUTEES ET REACTIONS AVEC LES ALCOOLS ET LES AMINES

The 2,4,5-trioxo-1,3-diaza-2-phospholidene trisubstituted, 3, are synthetized in the absence of any base, by the reaction of oxalyle chloride on the primary phosphordiamides 1.The 3 cycles are opened with a Formel bond cleavage in the presence of alcohols and a Formel one in the presence of amines.It can be assumed from the results that Formel pentacoordinate X complex is formed, whose breakdown in the case of amines is slower than the attack on one or the other of the carbonyles.