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Usage

Uses

Used in Pharmaceutical Synthesis:
2-(phenylsulfanyl)benzoyl chloride is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the creation of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Production:
In the agrochemical industry, 2-(phenylsulfanyl)benzoyl chloride serves as an essential building block for the preparation of various agrochemicals. Its role in the synthesis of these compounds helps address challenges in agriculture, such as pest control and crop protection.
Used in Fine Chemicals Manufacturing:
2-(phenylsulfanyl)benzoyl chloride is utilized as a crucial intermediate in the production of fine chemicals. Its presence in the synthesis process enables the creation of high-quality specialty chemicals used in various applications, including fragrances, dyes, and other industrial products.
Used as a Reagent in Polymer and Resin Production:
2-(phenylsulfanyl)benzoyl chloride is employed as a reagent in the manufacturing of polymers and resins. Its strong electrophilic properties make it suitable for reactions such as acylation and amidation, which are vital in the formation of polymers and resins with specific properties for various applications.
Safety Considerations:
Due to its reactivity and corrosive properties, it is crucial to handle 2-(phenylsulfanyl)benzoyl chloride with care. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be taken to minimize potential hazards during its use in chemical processes.

Upstream product

• 108-86-1 bromobenzene 
• 147-93-3 Thiosalicylic acid 
• 1527-12-4 2-(phenylthio)benzoic acid 

Downstream Products

• 176509-21-0 (2-Phenylsulfanyl-benzoyl)-phosphonic acid dimethyl ester 
• 492-22-8 thio-xanthene-9-one 

Relevant academic research and scientific papers

COMPOSITION AND METHOD FOR MANUFACTURING DEVICE USING SAME

An onium salt and a composition having high sensitivity and excellent pattern characteristics such as LWR, which is preferably used for a resist composition for a lithography process using two active energy rays of a first active energy ray such as an electron beam or an extreme ultraviolet and a second active energy ray such as UV.

Development of Potent Type i Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation

Protein Arginine Methyltransferases (PRMTs) are crucial players in diverse biological processes, and dysregulation of PRMTs has been linked to various human diseases, especially cancer. Therefore, small molecules targeting PRMTs have profound impact for both academic functional studies and clinical disease treatment. Here, we report the discovery of N1-(2-((2-chlorophenyl)thio)benzyl)-N1-methylethane-1,2-diamine (28d, DCPR049-12), a highly potent inhibitor of type I PRMTs that has good selectivity against a panel of other methyltransferases. Compound 28d effectively inhibits cell proliferation in several leukemia cell lines and reduces the cellular asymmetric arginine dimethylation levels. Serving as an effective inhibitor, 28d demonstrates the mechanism of cell killing in both cell cycle arrest and apoptotic effect as well as downregulation of the pivotal mixed lineage leukemia (MLL) fusion target genes such as HOXA9 and MEIS1, which reflects the critical roles of type I PRMTs in MLL leukemia. These studies present 28d as a valuable inhibitor to investigate the role of type I PRMTs in cancer and other diseases.

Reactions of carbene intermediates from the reaction of trialkyl phosphites with dialkyl benzoylphosphonates: Intramolecular cyclisations of 2-substituted dialkyl benzoylphosphonates

The reaction of dialkyl benzoylphosphonates 1 with trialkyl phosphites leads to the formation of carbene intermediates 3 via the anionic intermediates 2. The carbene intermediates 3 (R = 2-PhO, 2-PhOCH2, and 2-PhS) have been generated by heating the corresponding 2-substituted dialkyl benzoylphosphonates with trimethyl phosphite and their subsequent reactions investigated. Reactions proceed either by intermolecular trapping of the carbene intermediates by trimethyl phosphite to give novel ylidic phosphonates 4, or by intramolecular routes involving carbene insertion into the π-system of the phenyl ring in the substituent. Studies using methyl-substituted derivatives have shown that the formation of the thioxanthenylphosphonate 15 (X = S, R′ = R″ = Me) proceeds via a spiro diene intermediate 14 (X = S, R′ = R″ = Me).

PHOTOCHEMISTRY OF HYDROXAMIC ACIDS

Photochemical reactions of hydroxamic acids have been studied.The intermediacy of a RCONH(.) radical is postulated, based on oxidations achieved with DCA under photochemical conditions.