5374-29-8

Usage

Uses

Used in Pharmaceutical Industry:
(2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID is used as a pharmaceutical compound for its potential anti-inflammatory, antioxidant, and antimicrobial properties. Its diverse pharmacological activities make it a promising candidate for the development of new drugs to treat various diseases and conditions.
Used in Organic Synthesis:
(2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID is used as a precursor in organic synthesis. Its unique chemical structure allows it to be a valuable building block for the synthesis of other complex organic compounds, contributing to the advancement of chemical research and the development of new materials and products.
Used in Antimicrobial Applications:
(2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID is used as an antimicrobial agent due to its potential to inhibit the growth of various microorganisms. This property makes it a candidate for use in the development of new antimicrobial drugs and treatments, as well as in the preservation of food and other products.
Used in Antioxidant Applications:
(2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID is used as an antioxidant, which can help protect cells from damage caused by reactive oxygen species. Its antioxidant properties make it a potential candidate for use in the development of new therapies for various diseases and conditions associated with oxidative stress.
Used in Anti-inflammatory Applications:
(2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID is used as an anti-inflammatory agent, which can help reduce inflammation and alleviate symptoms associated with various inflammatory conditions. Its potential to modulate inflammatory processes makes it a promising candidate for the development of new treatments for inflammatory diseases.

InChI:InChI=1/C5H3NO4S/c7-3(8)1-2-4(9)6-5(10)11-2/h1H,(H,7,8)(H,6,9,10)/b2-1-

Upstream product

• 875-97-8 2-(2,4-dioxothiazolidin-5-yl)acetic acid 
• 701-23-5 (4-oxo-2-thioxo-thiazolidin-5-yl)-acetic acid 
• 5316-60-9 (4-oxo-2-thioxo-thiazolidin-5-ylidene)-acetic acid 

Downstream Products

• 875-97-8 2-(2,4-dioxothiazolidin-5-yl)acetic acid 
• 469875-38-5 N-(thiazol-2-yl)-2-(2,4-dioxothiazolidin-5-ylidene)acetamide 

Relevant academic research and scientific papers

Synthesis and in vitro antiproliferative and antibacterial activity of new thiazolidine-2,4-dione derivatives

In our present research, we synthesised new thiazolidine-2,4-diones (12–28). All the newly synthesised compounds were evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using normal human skin fibroblasts and tumour cell lines: A549, HepG2, and MCF-7. The IC50 values were determined for tested compounds revealing antiproliferative activity. Moreover, safety index (SI) was calculated. Among all tested derivatives, the compound 18 revealed the highest antiproliferative activity against human lung, breast, and liver cancer cells. More importantly, the derivative 18 showed meaningfully lower IC50 values when compared to the reference substance, irinotecan, and relatively high SI values. Moreover, newly synthesised compounds were screened for the bacteria growth inhibition in vitro. According to our screening results, most active compound was the derivative 18 against Gram-positive bacteria. Therefore, it may be implied that the novel compound 18 appears to be a very promising agent for anticancer treatment.

Synthesis of new potential anticancer agents based on 4-thiazolidinone and oleanane scaffolds

The synthesis and evaluation of the anticancer activity of new acylated oximes derivatives of oleanolic acid with 4-thiazolidinone-3(5)-carboxylic acid moieties were described. Newly synthesized compounds were elucidated on the basis of elemental analyses

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives

The synthesis and evaluation of anticancer activity of 2,4-thia(imida)zolidinedione-3- and 5-acetic acids amides were described. The structures of compounds were determined by IR, 1H NMR, and MS analysis. In vitro anticancer activity of these compounds has been tested in National Cancer Institute (NCI) and the relationships between structure and anticancer activity are discussed. Among 2,4-azolidinedione-acetic acids derivatives 2-[5-(4-chlorobenzylidene)-2,4-dioxo-imidazolidin-3-yl]-N-(2-trifluoromethyl-phenyl)-acetamide (Ic) was superior to other related compounds in terms of high selectivity for the leukemia CCRF-CEM (log GI50 = -6.06), HL-60(TB) (log GI50 = -6.53), MOLT-4 (log GI50 = -6.52) and SR (log GI50 = -6.51) cell lines.