53750-68-8Relevant academic research and scientific papers
Enantioselective synthesis of (1R,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-exo-carboxylic acid
Wirz, Beat,Spurr, Paul,Pfleger, Christophe
, p. 159 - 161 (2010)
A scalable enantioselective access to (1R,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-exo-carboxylic acid 7, a key precursor in the synthesis of A2a receptor antagonist 1 by means of an enzymatic resolution of the respective butyl ester with lipase A from Candida antarctica, is described.
BORONIC ACID DERIVATIVES
-
Page/Page column 45, (2019/03/12)
The present invention relates to a-amino boronic acid derivatives. These compounds are useful for inhibiting the activity of immunoproteasome (LMP7) and for the treatment and/or prevention of medical contidions affected by immunoproteasome activity such as inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer.
N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities
-
Paragraph 0249, (2014/09/29)
Described are compounds of Formula 1 which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities
-
Paragraph 0391, (2014/09/30)
Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
Niobium(V) chloride as catalyst in diels-alder reaction of furan ring
Santos, Deborah A. Dos,Rodrigues, Ludmila R.,Arpini, Bruno H.,Lacerda Jr., Valdemar,Greco, Sandro J.,Santos, Reginaldo B. Dos,Neto, A?lvaro C.,Roma?oa, Wanderson,De Castro, Eustaquio V.R.
, p. 882 - 886 (2014/06/24)
According to the relevant literature, the Diels-Alder reaction of furan without a catalyst can last several weeks and shows a low yield due to the diene's low reactivity. The use of Lewis acid catalysts or high pressures is described as an effective method for improving the reaction yields. This paper describes our recent study on the use of niobium pentachloride as the catalyst in Diels-Alder reactions between furan and several reactive dienophiles, among which methyl acrylate showed good yields, especially at lower temperatures. Other dienophiles have shown lower yields because of problems such as byproduct formation and the high reversibility of the reaction.
PROCESS FOR THE MANUFACTURE OF 7-OXA-BICYCLO DERIVATIVES
-
Page/Page column 3-4, (2008/12/06)
The present invention relates to a process for the manufacture of the 7-oxabicyclo derivative of the formula I
Effect of water on chemo- and endo-selectivity in high pressure Diels-Alder furan reactions. Hydrophobic or polar effects?
Jenner, Gerard
, p. 1189 - 1192 (2007/10/02)
Diels-Alder furan additions are less sensitive to pressure in aqueous solution than in organic solvents. In some cases, water affects chemo- and stereoselectivity. The interpretation takes into account hydrophobic as well as polar effects induced by water.
ON THE LEWIS ACID CATALYZED DIELS-ALDER REACTION OF FURAN. REGIO- AND STEREOSPECIFIC SYNTHESIS OF SUBSTITUTED CYCLOHEXENOLS AND CYCLOHEXADIENOLS.
Brion, Francis
, p. 5299 - 5302 (2007/10/02)
The cycloaddition between furan and some dienophiles can be greatly accelerated in the presence of a Lewis-Acid (i. e.ZnI2).The 7-oxabicycloheptyl system readily undergoes a base promoted β-elimination of the heteroatom bridge leading to subs
