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1,1-dimethyl-3,5-dimethylenepiperidinium chloride, commonly referred to as MPP+ chloride, is a toxic chemical compound that serves as a significant tool in scientific research for the study of neurodegenerative diseases, particularly Parkinson's disease. It is a positively charged molecule with the ability to cross the blood-brain barrier, where it accumulates in dopaminergic neurons, inhibiting the mitochondrial electron transport chain's complex I and leading to neuronal cell death. 1,1-dimethyl-3,5-dimethylenepiperidinium chloride's toxic properties have been instrumental in advancing the understanding of neurodegenerative mechanisms and in the development of potential therapeutic interventions.

53754-71-5

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53754-71-5 Usage

Uses

Used in Scientific Research:
1,1-dimethyl-3,5-dimethylenepiperidinium chloride is used as a research tool for [studying the mechanisms of neurodegeneration] because of its ability to model the effects of neurodegenerative diseases such as Parkinson's disease. It provides insights into the cellular and molecular pathways affected by such diseases, aiding in the discovery of potential therapeutic targets.
Used in Drug Development:
MPP+ chloride is used as a pharmacological agent for [screening and testing potential neuroprotective compounds] in the development of treatments for Parkinson's disease and related neurodegenerative conditions. Its role in inducing a Parkinson's-like state in laboratory models allows researchers to evaluate the efficacy of new drugs in preventing or reversing the toxic effects associated with the disease.
Used in Toxicology Studies:
1,1-dimethyl-3,5-dimethylenepiperidinium chloride is used as a toxicological agent for [investigating the effects of mitochondrial inhibition and oxidative stress] on neuronal cells. This helps in understanding the broader implications of such cellular stressors in the context of various toxicological and environmental exposures.
Used in Neurobiology:
MPP+ chloride is used as a neurobiological probe for [exploring the function and vulnerability of dopaminergic neurons], which are particularly affected in Parkinson's disease. This application aids in unraveling the intricate workings of these neurons and their response to toxic insults.

Check Digit Verification of cas no

The CAS Registry Mumber 53754-71-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,5 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 53754-71:
(7*5)+(6*3)+(5*7)+(4*5)+(3*4)+(2*7)+(1*1)=135
135 % 10 = 5
So 53754-71-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H16N.ClH/c1-8-5-9(2)7-10(3,4)6-8;/h1-2,5-7H2,3-4H3;1H/q+1;/p-1

53754-71-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,1-dimethyl-3,5-dimethylidenepiperidin-1-ium,chloride

1.2 Other means of identification

Product number -
Other names 1,1-Dimethyl-3,5-dimethylenepiperidinium chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:53754-71-5 SDS

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