53757-45-2Relevant academic research and scientific papers
Chemistry and pharmacology of apiose. 7. Susceptibility of some branched chain sugar nucleosides to enzymatic deamination
Tronchet,Tronchet,Graf
, p. 1055 - 1056 (1974)
The synthesis of a new branched chain sugar nucleoside 9 (5 deoxy 3 C hydroxymethyl β D xylofuranosyl) adenine is described. This compound and 9 (3 C hydroxymethyl α L threofuranosyl) adenine are substrates of calf adenosine deaminase whereas the 3' epimer of the second compound is not deaminated. This shows that a C 3' carbon ramification on a nucleoside does not always abolish susceptibility to enzymatic deamination and that the configuration at the branching point plays an important role in substrate specificity.
