537653-28-4

Basic information

• Product Name: 5H-Thiazolo[3,2-a]pyrimidin-3(2H)-one, 2-methyl-5-(3-nitrophenyl)-7-phenyl-
• CAS NO: 537653-28-4
• Molecular Formula: C19H15N3O3S
• Molecular Weight: 365.412
• Mol File: 537653-28-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5H-Thiazolo[3,2-a]pyrimidin-3(2H)-one, 2-methyl-5-(3-nitrophenyl)-7-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Thiazolo[3,2-a]pyrimidin-3(2H)-one, 2-methyl-5-(3-nitrophenyl)-7-phenyl-(537653-28-4)
• EPA Substance Registry System: 5H-Thiazolo[3,2-a]pyrimidin-3(2H)-one, 2-methyl-5-(3-nitrophenyl)-7-phenyl-(537653-28-4)

Safety Data

• Hazardous Substances Data: 537653-28-4(Hazardous Substances Data)

Usage

General Description

5H-Thiazolo[3,2-a]pyrimidin-3(2H)-one, 2-methyl-5-(3-nitrophenyl)-7-phenyl- is a chemical compound with the molecular formula C18H12N4O3S. It is a thiazole-based organic compound with a pyrimidine ring and a phenyl group. The compound also contains a nitrophenyl and a methyl group. It is used in organic synthesis and has potential pharmaceutical applications due to its unique structure and properties. The compound's biological and chemical properties make it a subject of interest for further research and potential applications in the pharmaceutical and chemical industries.

Upstream product

• 614-48-2 (E)-3-nitrochalcone 
• 598-72-1 2-Bromopropionic acid 
• 537653-10-4 4-(3-nitro-phenyl)-6-phenyl-3,4-dihydro-1H-pyrimidine-2-thione 

Relevant articles and documents

Synthesis and reactions of some new 2,3-dihydro-5H-5,7-diarylthiazolo-[3,2-a]pyrimidine-3-one derivatives and their antibacterial and fungicidal activity

Arylmethylene acetophenone derivatives (chalcones) Ia-d react with thiourea in glacial acetic acid CH3COOH/Ac2O in the presence of anhydrous sodium acetate to yield 1,4-dihydro-4,6-diarylpyrimidine-2-thione 2a-d which on treatment with chloroacetic acid furnish 2,3-dihydro-5H-5,7-diaryl thiazolo[3,2-a]pyrimidine-3-one derivatives 3a-d. Compounds 3a-d on condensation with aromatic aldehydes yield 2(arylmethylene)-2,3-dihydro-5H-5,7-diaryl-thiazolo[3,2-a]pyrimidine-3-one derivatives 4a-f. Also compounds 4a-d have been prepared directly from 2a,b by the reaction with chloroacetic acid and the aromatic aldehyde. Coupling of 3a-d with aryl diazonium salts in pyridine yields 2-(aryl hydrazo)-2,3-dihydro-5,7-diaryl- 5H-thiazolo[3,2-a]pyrimidine-3-ones 5a-f. Compounds 2a-d on reaction with 2-bromopropionic or 3-bromopropionic acid give 2,3-dihydro-2-methyl-5H-5,7-diaryl-thiazolo[3,2-a]pyrimidine-3-one 6a-d and 2,3-dihydro-6H-6,8-diaryl-pyrimido- [3,2-b]-1,3-thiazin-4-ones 7a-d respectively. A number of 3,4-dihydro-4,6-diaryl pyrimidine-2yl-thio)acetahydrazide 8a-c, 2-(3,4-dihydro-4,6-d[aryl-pyrimidine-2yl-thio)acetanilide derivatives 8d-g, 2-(3,4-dihydro-4,6-diaryl-pyrimidine-2yl-thio)- propionylhydrazide 9a-c, 2-(3,4-dihydro-4,6-diaryl-pyrimidine-2yl-thio)propionylanilide 9d-f and 3-(3,4-dihydro-4,6-diaryipyrimidine-2yl-thio)propionamide 10a-e derivatives are readily obtained in good yield by the action of the corresponding amines on compounds 3, 6 or 7 successively. The anilide 8d also has been obtained by the reaction of compound 2a with chloroacetanilide.