537698-46-7Relevant academic research and scientific papers
Regioselective synthesis of 1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones: Kinetic studies and selective pyrolytic deprotection
Al-Awadi, Nouria A.,Ibrahim, Yehia A.,Kaul, Kamini,Dib, Hicham
, p. 50 - 55 (2007/10/03)
Selective pyrolytic deprotection of 2-ethyl and 2-cyanoethyl-4-arylidenimino-1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones was studied by flash vacuum pyrolysis. This study is useful in regioselective synthesis of 2-and 4-substituted 1,2,4-triazoles of potential biological applications. The kinetic results and product analysis lend support to a reaction pathway involving a six-membered transition state.
Gas-phase elimination reactions of 4-arylideneimino-2-cyanoethyl-1,2,4-triazol-3(2H)-ones, their thione analogues and 2-glucosyl-1,2,4-triazole-3(2H)-thiones: A kinetic and mechanistic study
Al-Awadi, Nouria A.,Ibrahim, Yehia A.,Dib, Hicham,Kaul, Kamini
, p. 324 - 329 (2007/10/03)
Several 4-arylidenimino-2-cyanoethyl-1,2,4-triazol-3(2H)-ones, their 3(2H)-thiones and 2-glucosyl-1,2,4-triazol-3(2H)-thiones (1-12) were synthesized. Selective pyrolytic deprotection of these derivatives was studied in the gas phase and the kinetics of the reactions were measured for each compound. First-order rate constants measured over a 45 °C temperature range were used to calculate the Arrhenius activation parameters. A comparison of the products and the kinetic behavior of the thermal decomposition of these compounds are discussed. Copyright
