537718-07-3Relevant academic research and scientific papers
A chemobiological synthesis of eplerenone
Wuts, Peter G. M.,Anderson, Andrew M.,Ashford, Scott W.,Goble, Michael P.,White, Michael J.,Beck, Doris,Gilbert, Ivan,Hrab
, p. 418 - 422 (2008/09/17)
This paper will describe an approach to the synthesis of eplerenone, which is being marketed for the treatment of hypertension. The synthesis begins with DHEA available from wild yams and uses a combination of microbiological and chemical transformations to build eplerenone. Georg Thieme Verlag Stuttgart.
Processes for preparing C-7 substituted steroids
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Page/Page column 9, (2008/06/13)
This invention relates to processes for the preparation of novel 7-carboxy substituted steroid compounds of Formula I,
Microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters
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, (2008/06/13)
A microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters is disclosed.
Processes for preparing 7-carboxy substituted steroids
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Page 16, (2008/06/13)
This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, wherein R1 is selected from H or COR4; R4 is C1-C6 alkyl or C1-C6 alkoxy; R3 is C1-C6 alkyl; Z1 is —CH2— or wherein O—COR4 is in the α configuration; Z2 is —CH—; or Z1 and Z2 may be taken together to form a carbon-carbon double bond; Q is These intermediates are useful in the preparation of 7-carboxy substituted steroid compounds, and particularly, the invention is directed to novel and advantageous methods for the preparation of 9,11-α-epoxy-17-α-hydroxy-3-oxopregn-4-ene-α-7-21-dicarboxylic acid, γ-lactone, methyl ester (eplerenone; epoxymexrenone).
