537718-20-0Relevant articles and documents
Processes for preparing 7-carboxy substituted steroids
-
Page 5, (2008/06/13)
This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, wherein R1 is selected from H or COR4; R4 is C1-C6 alkyl or C1-C6 alkoxy; R3 is C1-C6 alkyl; Z1 is —CH2— or wherein O—COR4 is in the α configuration; Z2 is —CH—; or Z1 and Z2 may be taken together to form a carbon-carbon double bond; Q is These intermediates are useful in the preparation of 7-carboxy substituted steroid compounds, and particularly, the invention is directed to novel and advantageous methods for the preparation of 9,11-α-epoxy-17-α-hydroxy-3-oxopregn-4-ene-α-7-21-dicarboxylic acid, γ-lactone, methyl ester (eplerenone; epoxymexrenone).