53774-30-4Relevant academic research and scientific papers
Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition
Xu, Ke,Li, Wenchang,Zhu, Shaoheng,Zhu, Tingshun
supporting information, p. 17625 - 17630 (2019/11/29)
Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N-heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.
Synthesis, biological activity and structure-activity relationship of 4,5-dimethoxybenzene derivatives inhibitor of rhinovirus 14 infection
Roche, Manon,Lacroix, Céline,Khoumeri, Omar,Franco, David,Neyts, Johan,Terme, Thierry,Leyssen, Pieter,Vanelle, Patrice
, p. 445 - 459 (2014/03/21)
Human rhinoviruses are a common cause of respiratory infections, and thus constitute an important target for medicinal chemistry. Still, no drug has been approved for clinical use. We report herein the discovery of dibenzenic derivatives with potent and s
