53777-19-8

Upstream product

• 61760-40-5 3r-benzyl-6c-hydroxymethyl-3,6t-bis-methoxymethylsulfanyl-1,4-dimethyl-piperazine-2,5-dione 
• 79247-60-2 (3S,6S)-3-Benzyl-6-methoxymethyl-3,6-bis-methoxymethylsulfanyl-1,4-dimethyl-piperazine-2,5-dione 
• 100-39-0 benzyl bromide 
• 61760-32-5 (3R,6R)-3,6-Bis-methoxymethylsulfanyl-1,4-dimethyl-piperazine-2,5-dione 
• 147900-76-3 2,3,5-trioxo-1,4-dimethylpiperazine 
• 21579-45-3 1,4-dimethyl-2,5-diketopiperazine-3,6-dibromide 
• 5076-82-4 sarcosine anhydride 
• 19552-97-7 1,4-dimethyl-3,6-dioxopiperazine-2,5-diyl diethanethioate 
• 19552-98-8 3,6-dimercapto-1,4-dimethylpiperazine-2,5-dione 
• 71742-24-0 1,4-Dimethyl-3-formyl-2,5-piperazinedione 
• 73454-06-5 1,4-Dimethyl-3-<<(tert-butyldiphenylsilyl)oxy>methylene>-6-mercapto-6-benzyl-2,5-piperazinedione 
• 71742-28-4 1,4-Dimethyl-3-<<(tert-butyldiphenylsilyl)oxy>methylene>-6-benzyl-2,5-piperazinedione 

Downstream Products

• 52748-85-3 1-benzyl-6-hydroxymethyl-7,9-dimethyl-2,3,4,5-tetrathia-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione 
• 52748-85-3 (1S)-1-benzyl-6-hydroxymethyl-7,9-dimethyl-2,3,4,5-tetrathia-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione 

Relevant academic research and scientific papers

A Modular Construction of Epidithiodiketopiperazines

Epidithiodiketopiperazines (ETPs) possess remarkably diverse biological activities and have attracted significant synthetic attention. The preparation of analogues is actively pursued; however, they are structurally challenging, and more direct and modular methods for their synthesis are desirable. To this end, the utility of a bifunctional triketopiperazine building block for the straightforward synthesis of ETPs is reported. A modular strategy consisting of enolate alkylation followed by site-selective nucleophile addition enables the concise synthesis of (±)-hyalodendrin and a range of analogues.

A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)-Clausenamide and the Total Synthesis of (±)-Hyalodendrin

Structurally diverse natural products from unrelated sources typically require the development of individual synthetic routes. In a novel approach, we have shown that the epidithiodiketopiperazine-derived natural product (±)-hyalodendrin and the core structure of the unrelated pyrrolidine-derived natural product clausenamide can be synthesised from a common synthetic precursor in good yield by simple variation of the reaction conditions. Structurally unrelated natural products often require individual synthetic routes. In our approach, the epidithiodiketopiperazine natural product (±)-hyalodendrin and the core structure of the unrelated pyrrolidine-derived natural product clausenamide were synthesised from a common precursor by simple variation of the reaction conditions.

COMPOSITIONS AND METHODS FOR INHIBITING ACTIVITY OF HYPOXIA-INDUCIBLE TRANSCRIPTION FACTOR COMPLEX AND ITS USE FOR TREATMENT OF TUMORS

Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes. An embodiment of the present invention is directed to a method for interfering with hypoxia-induced transcriptional pathway. Generally, the method according to this embodiment comprises contacting a cell with at least one compound according to either Formula I, Formula II or Formula III, or a salt, solvent or hydrate thereof.

TOTAL SYNTHESIS OF GLIOTOXIN, DEHYDROGLIOTOXIN AND HYALODENDRIN

Two general methods, Method A and Method B in Scheme 19, to synthesize epidithiapiperazinediones, are described.A total synthesis of racemic and optically active gliotoxin (1) and of racemic dehydrogliotoxin (53) was achieved by using Method A, whereas a total synthesis of racemic hyalodendrin (52) was completed by using Method B.