5378-32-5

Usage

Chemical class

2-(3-fluorophenyl)-1,3,4-oxadiazole belongs to the oxadiazole class of compounds.

Ring structure

It has a 1,3,4-oxadiazole ring structure.

Fluorophenyl group

A fluorophenyl group is attached at the 2-position of the ring structure.

Potential biological and pharmaceutical activities

2-(3-fluorophenyl)-1,3,4-oxadiazole has been studied for its potential biological and pharmaceutical activities.

Building block in synthesis

It can be used as a building block in the synthesis of various pharmaceuticals and agrochemicals.

Unique structure and pharmacological properties

Its unique structure and potential pharmacological properties make it a valuable compound for further research and development in the field of medicinal chemistry.

Upstream product

• 455-38-9 3-fluorobenzoic acid 
• 73789-56-7 N-isocyaniminotriphenylphosphorane 
• 499-55-8 3-fluoro-benzoic acid hydrazide 
• 122-51-0 orthoformic acid triethyl ester 

Relevant academic research and scientific papers

Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors

A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivatives, (3R)-3-amino-N-(4-(4-phenylthiazol-2-yl)-tetrahydro-2H- thiopyran-4-yl)-4-(2,4,5-trifluorophenyl)butanamide 1,1-dioxide (30) reduced blood glucose excursion in an oral glucose tolerance test by oral administration.

(N-Isocyanimino)triphenylphosphorane as an Efficient reagent for the synthesis of 1,3,4-Oxadiazoles from 3-substituted benzoic acid derivatives

The reaction of 3-substituted benzoic acid derivatives with (N-isocyanimino) triphenylphosphorane proceeds smoothly at room temperature to afford corresponding 1,3,4-oxadiazoles via an intramolecular aza-Wittig reaction in excellent yields under neutral c