5378-84-7

Upstream product

• 64062-91-5 2-<4-(Chlorosulfonyl)phenyl>ethyl bromide 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 4796-29-6 C₁₅H₂₁BrN₂O₃S 
• 1207340-23-5 4-[(1-(4-sulfonamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline 
• 92648-94-7 C₁₅H₂₀N₂O₃S 
• 1565-37-3 4-(1,2-dibromo-ethyl)-benzenesulfonic acid amide 
• 119745-55-0 [(S)-1-{(R)-1-[({Ethyl-[2-(4-sulfamoyl-phenyl)-ethyl]-carbamoyl}-methyl)-carbamoyl]-4-guanidino-butylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 119744-98-8 ({Ethyl-[2-(4-sulfamoyl-phenyl)-ethyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester 
• 2633-64-9 4-vinylbenzenesulfonamide 

Relevant academic research and scientific papers

BIS-(4-HALOETHYLBENZENESULFONYL)IMIDE OR ITS SALT, METHOD FOR PRODUCING THE SAME AND METHOD FOR PRODUCING BIS-(4-STYRENESULFONYL)IMIDE OR ITS SALT USING BIS-(4-HALOETHYLBENZENESULFONYL)IMIDE AS PRECURSOR

PROBLEM TO BE SOLVED: To provide a method for producing bis-(4-styrenesulfonyl)imide or its salt which is excellent in radical polymerizability, cation exchangeability and high water-solubility and is extremely useful for producing an ion exchange membran

BIS-(4-HALOETHYLBENZENESULFONYL)IMIDE OR ITS SALT, METHOD FOR PRODUCING THE SAME AND METHOD FOR PRODUCING BIS-(4-STYRENESULFONYL)IMIDE OR ITS SALT USING BIS-(4-HALOETHYLBENZENESULFONYL)IMIDE AS PRECURSOR

PROBLEM TO BE SOLVED: To provide bis-(4-styrenesulfonyl)imide or its salt which is a crosslinkable monomer having excellent radical polymerizability, cation exchangeability and high water-solubility and is extremely useful for producing a solid electrolyt

COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT

Compound of formula (I) in which R1, R2 and R3 are defined in the following description, and the pharmaceutically acceptable acid-addition or base-addition salts thereof. The invention also relates to a process and an intermediate for preparing it, and to a pharmaceutical composition comprising it. The invention also relates to the use of a novel 2H-pyrrolo[3,4-c]quinoline compound for preparing a pharmaceutical composition that is active in the treatment of disturbances of the serotoninergic system.

Peripherally Acting Enkephalin Analogues. 2. Polar Tri- and Tetrapeptides

The design, synthesis, and biological activity of a series of -Arg2-enkephalin-derived tetrapeptide amides and tripeptide aralkylamides are reported.These polar analogues were designed to be excluded from the central nervous system with their action thus limited to peripheral opioid receptors.The effects of the nature of the aromatic ring, aryl ring substitution, and aralkylamine chain length on activity were investigated; in a number of cases the N-terminal amino group of Tyr1 was converted to a guanidino group to further increase hydrophilicity.The peptides were all synthesized by classical solution methodology.The opioid activit y of the peptides was assessed in vitro on the guinea pig ileum and their antinociceptive activity was determined in vivo in chemically induced writhing models (peripheral activity) and in the hot-plate test (central activity), in rodents.That the analgesic effects were predominantly mediated in the periphery was demonstrated by antagonism of antinociception by the peripheral opioid antagonist N-methylnalorphine and by comparison of the activities in the writhing and hot-plate tests.As a class, the tetrapeptides were more potent than the tripeptides; Nα-amidination generally increased activity.A number of compounds exhibited very potent opioid activity and had the desired pharmacological profile, indicating a high degree of peripheral selectivity.

Monomeric disulfonimides

The invention provides disulfonimide compounds of the general formula STR1 wherein X is bromine, chlorine or iodine; R is hydrogen or methyl; and R' is alkyl, aryl or substituted aryl. The compounds are useful as activators for anaerobic adhesive composit