53786-87-1Relevant academic research and scientific papers
One-pot synthesis of indene derivatives by CF3SO 3H-promoted reactions of benzylic alcohols and 1,3-dicarbonyl compounds
Zhang, Wei,Zhang, Wenxue,Dai, Yisi,Zhu, Haizhen
, p. 1747 - 1750 (2013/03/28)
An efficient and convenient one-pot synthesis of indene derivatives was achieved in moderate to high yields by the CF3SO3H promoted coupling/cyclization reaction of benzylic alcohols and 1,3-dicarbonyls for the first time. For the reactions of methoxy- or methyl-substituted diarylmethanols with 1,3-dicarbonyls, 2 equiv of CF3SO3H was needed to reach the best results; but for the reactions of methoxy-substituted arylethanols with 1,3-dicarbonyls, 0.6 equiv of CF 3SO3H at lower temperatures was capable of promoting the reaction finished.
