53792-97-5

Basic information

• Product Name: Cinepazide Impurity 1
• Synonyms: Cinepazide Impurity 1;Cinepazide Impurity G
• CAS NO: 53792-97-5
• Molecular Formula: C₁₆H₂₂N₂O₄
• Molecular Weight: 306.36
• Mol File: 53792-97-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 512.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.153±0.06 g/cm3(Predicted)
• PKA: 8.38±0.10(Predicted)
• CAS DataBase Reference: Cinepazide Impurity 1(CAS DataBase Reference)
• NIST Chemistry Reference: Cinepazide Impurity 1(53792-97-5)
• EPA Substance Registry System: Cinepazide Impurity 1(53792-97-5)

Safety Data

• Hazardous Substances Data: 53792-97-5(Hazardous Substances Data)

Upstream product

• 1374250-20-0 tert-butyl 4-[(E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-1-piperazinecarboxylate 
• 10263-19-1 3',4',5'-trimethoxycinnamoyl chloride 
• 90-50-6 3,4,5-trimethoxycinnamic acid 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Relevant articles and documents

Pyridazinone derivative, and preparation method and medical application thereof

The invention provides a pyridazinone derivative, and a preparation method and a medical application thereof. O-formylbenzoic acid used as a raw material reacts with dimethyl phosphite to obtain dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate, the dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate reacts with 3-cyano-4-fluorobenzaldehyde in the presence of triethylamine to prepare (Z,E)-2-fluoro-5-[(3-oxoisobenzofuran-1(3H)-ylidene)methyl]benzonitrile, and the (Z,E)-2-fluoro-5-[(3-oxoisobenzofuran-1(3H)-ylidene)methyl]benzonitrile is reduced by hydrazine hydrate to prepare 2-fluoro-5-[(4-oxo-3,4-dihydropyridazin-1-yl)methyl]benzoic acid; and benzaldehyde or substituted aromatic formaldehyde or furfural used as a raw material and malonic acid undergo a Knoevenagel reaction to obtain cinnamic acid or substituted cinnamic acid or furan-2-acrylic acid, the cinnamic acid or substituted cinnamic acid or furan-2-acrylic acid and 1-tert-butoxycarbonylpiperazine undergo an amidation reaction, a tert-butoxycarbonyl group is removed from the obtained amidation product in the presence of trifluoroacetic acid, and the obtained product and the 2-fluoro-5-[(4-oxo-3,4-dihydropyridazin-1-yl)methyl]benzoic acid undergo the amidation reaction to obtain a series of (E)-4-{3-[4-[(3-substituted aryl)acryloyl]piperazin-1-carbonyl]-4-fluorobenzyl}-2H-pyridazin-1-one derivatives. Results of preliminary pharmacological activity screening show that the compound represented by a general formula shown in the present invention has a certain in-vitro PARP-1 inhibition ability and a certain in-vitro tumor cell proliferation resisting activity. The structural general formula of compound is shown in the description; and in the general formula, Ar is selected from two formulas also shown in the description, and R1, R2, R3, R3, R4 and R5 can be the hydrogen atom, the fluorine atom, the chlorine atom, the bromine atom, a methyl group, a methoxy group, a tetrafluoromethyl group and a nitro group.