53798-07-5Relevant academic research and scientific papers
Convergent synthesis of the spiroketal core of the HIV-1 protease inhibitors the didemnaketals
Jia, Yanxing,Li, Xin,Wang, Pingzhen,Wu, Bin,Zhao, Xuezhi,Tu, Yongqiang
, p. 565 - 570 (2002)
A stereocontrolled and efficient synthetic approach to the spiroketal compound 4a and its C1″-epimer 4b, the core of the HIV-protease inhibitor didemnaketals isolated from the ascidian Didemnum sp., is developed through a multistep approach from natural L
Synthetic studies of didemnaketal analogue - Construction of the (+)- and (-)-5,6-dihydroxy-3,7-dimethyl-octanal intermediates
Wang, Ping Zhen,Tu, Yong Qiang,Yang, Li,Dong, Chang Zhi,Kitching, William
, p. 3789 - 3795 (2007/10/03)
A synthetic procedure for construction of the (+)-(3R,5R,6R)-5,6- dihydroxy-3,7-dimethyl-octanal and (-)(3S,5S,6S)-5,6-dihydroxy-3,7-dimethyl- octanal derivatives, the intermediates for synthesis of the HIV-active di- demnaketal analogue, was developed via a series of reactions from the natural (-)-menthone.
