53799-94-3

Upstream product

• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 106-96-7 propargyl bromide 
• 558-13-4 carbon tetrabromide 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 364765-25-3 4-(3-methoxyphenyl)-1-(2-thienyl)-2-butyn-1-ol 
• 1607804-50-1 (1-benzyl-1H-1,2,3-triazol-4-yl)(3-methoxyphenyl)methanone 
• 1607804-59-0 1-benzyl-4-(3-methoxybenzyl)-1H-1,2,3-triazole 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 238424-25-4 4-(3-methoxyphenyl)-1-(2-thienyl)-2-butyn-1-one 

Relevant academic research and scientific papers

Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors

To identify a new non-peptidyl BACE1 inhibitor, we focused on the aminopyridine structure, which binds to the active sites of BACE1. Synthesis of aminopyridine derivatives and evaluation of inhibitory activity against rBACE1 are described. The 2-aminopyri

Synthesis of allenes via Nickel-catalyzed cross-coupling reaction of propargylic bromides with grignard reagents

We describe a convenient method for the synthesis of terminal allenes from cross-coupling of propargylic bromide with Grignard reagent. The reaction of propargylic bromide with 1.2 equivalents of Grignard reagent mediated by Ni(acac)2 (2 mol%) and Ph3P (4 mol%) in THF may produce terminal allenes in good yields and high regioselectivities at room temperature. Georg Thieme Verlag Stuttgart · New York.