5381-29-3

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-3-(1-BENZOTHIEN-3-YL)ACRYLIC ACID is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological activities, which have been studied for the treatment of various diseases and conditions.
Used in Organic Synthesis:
(2E)-3-(1-BENZOTHIEN-3-YL)ACRYLIC ACID is used as a building block in organic synthesis for the creation of other organic molecules and materials, owing to its unique chemical structure and reactivity.

Upstream product

• 5381-20-4 benzothiophene-3-carboxaldehyde 
• 141-82-2 malonic acid 
• 1956-23-6 (R)-α-amino-3-[1]benzothiophene-3-ylpropionic acid 
• 72120-71-9 (S)-2-amino-3-<1>benzothiophene-3-ylpropionic acid 
• 110-89-4 piperidine 
• 95-15-8 Benzo[b]thiophene 
• 3216-47-5 3-chloromethylbenzothiophene 

Downstream Products

• 195520-09-3 (E)-3-(2-nitrovinyl)benzo[b]thiophene 
• 26461-80-3 3-benzo[b]thiophen-3-yl-propionic acid 

Relevant academic research and scientific papers

One-pot synthesis of fused 2-pyridones from heteroarylacrylic acid via curtius rearrangement & microwave-assisted thermal electrocyclization

We investigated the one-pot synthesis of several fused 2-pyridone ring systems based on a Curtius rearrangement, followed by a microwave-assisted thermal electrocyclization of a 2-aza-6?-electron system including isocyanate. We synthesized seven heterocyclic compounds containing a fused 2-pyridone ring. In these results, the one-pot synthesis of fused 2-pyridone ring system 5 from (E)-acrylic acids 1 under microwave irradiation conditions was more effective than the conventional reaction conditions in terms of the yield and the reaction time.

The interaction of heteroaryl-acrylates and alanines with phenylalanine ammonia-lyase from parsley

Acrylic acids and alanines substituted with heteroaryl groups at the β-position were synthesized and spectroscopically characterized (UV, HRMS, 1H NMR, and 13C NMR spectroscopy). The heteroaryl groups were furanyl, thiophenyl, benzofuranyl, and benzothiophenyl and contained the alanyl side chains either at the 2- or 3-positions. While the former are good substrates for phenylalanine ammonia lyase (PAL), the latter compounds are inhibitors. Exceptions are thiophen-3-yl-alanine, a moderate substrate and furan-3-yl-alanine, which is inert. Possible reasons for these exceptions are discussed. Starting from racemic het eroaryl-2-alanines their D-enantiomers were prepared by using a stereodestructive procedure. From the heteroaryl-2- acrylates, the L-enantiomers of the heteroaryl-2-alanines were prepared at high ammonia concentration. These results can be best explained by a Friedel - Crafts-type electrophilic attack at the aromatic part of the substrates as the initial step of the PAL reaction.

Calcitonin gene related peptide receptor antagonists

The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS

The presnt invention relates to compounds of Formula (I), as antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.