5381-98-6

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 5381-98-6 differently. You can refer to the following data:
1. A enicillin-Like?inhibitor of ?Lactamases
2. A “Penicillin-Like”-inhibitor of β-Lactamases.

InChI:InChI=1/C7H4ClO4P/c8-13(10)11-6-4-2-1-3-5(6)7(9)12-13/h1-4H

Upstream product

• 69-72-7 salicylic acid 
• 6099-41-8 2-dichlorophosphoryloxy-benzoyl chloride 

Relevant academic research and scientific papers

Novel phosphorus-containing silazanes as flame retardants in epoxy resins

Molecules containing different elements and moieties like P-N and P-O-Si have high impact on flame retardant properties. In this study, a novel group of flame retardants based on phosphasilazanes containing a P-N-Si structure is established. Due to introduction of the silazane moiety to various phosphorus environments, further properties, like mechanical or thermal, besides flame retardancy can be altered. The influence of phosphorus or silicon moieties and their mode of action on flame retardant properties is examined. In formulations with a high-performance epoxy resin, thermal properties (glass transition temperature and moisture absorption) and flame retardant performance (UL94 vertical burning test, cone calorimetry) are investigated. Alteration of chemical environment at the phosphorus atom determines various implications on burning behavior. For example, phosphorus-containing moieties promoting char generation and intumescence enhance char yields and other parameters describing flame retardant properties of phosphasilazanes in thermo-analysis as well as in cone calorimetry. On the other hand, higher concentration of silazane groups in the structure leads to higher flammability. Phosphorus moieties acting in gaseous phase cause poor flame retardant properties because they antagonize the char generation of silazanes.

DERIVATIVES OF CYCLOHEXANE-1,2-DIOL-PHOSPHOROCHLORIDATE AND 1-CHLOR-4,5-BENZ-2,6-DIOXAPHOSPHORINANONE-(3) 1-OXIDE

Cyclohexane 1,2-diol (1) has been phosphorylated to the cyclic phosphorochloridate (2; X=O) and chloridothioate (2; X=S).Hydrolysis of the former with boiling aqueous acetone gave 2-hydroxycyclohexyl dihydrogen phosphate (3; X=O, R=H) and excess isopropyl alcohol gave the diisopropyl phosphate (3; X=O, R=(CH3)2CH).Reaction of the chloridate (2; X=O) with aniline, diethylamine, and morpholine gave the corresponding amidates (4-6).The chloridothioate (2; X=S) similarly gave amidates (8, 9) with morpholine and aniline, but with isopropyl alcohol the cyclic isopropyl phosphate (10) was obtai ned.Attempted hydrolysis (aqueous acetone) of the chloridothioate (2; X=S) resulted in decomposition.Salicylic acid (11) with phosphorus oxychloride gave the cyclic phosphorochloridate (12) which reacted with ethanol, propanol, isopropyl alcohol and benzyl alcohol to give the alkoxy derivatives (13-16).The highly sterically hindered alcohols, t-butanol and benzhydrol did not react.The alkoxy derivatives were hydrolyzed to the corresponding 2-carboxyphenyl phosphates (17-20).Attempted reaction of the chloridate (12) with aniline gave complex mixtures of unidentified products.The proton n.m.r., i.r. and ms. of the compounds (12-20) are briefly discussed.