53811-83-9

Upstream product

• 72833-59-1 1-benzyl-2-(p-chlorophenyl)-3-(p-chlorobenzyl)-5-methylbenzimidazoline 
• 106-49-0 p-toluidine 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 7628-80-0 N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-p-tolyl-hydrazine 
• 213966-05-3 1-(4-chlorobenzylidene)-2-benzyl-2-p-tolylhydrazine 

Relevant academic research and scientific papers

Copper-mediated synthesis of substituted 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles via C-H functionalization/C-N/C-O bond formation

An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime ethers to functionalized 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles is described. The protocol involves a copper(II)-mediated cascade C-H functionalization/C-N/C-O bond formation under neutral conditions. Substrates having either electron-donating or -withdrawing substituents undergo the cyclization to afford the target heterocycles at moderate temperature.

Pyrolysis of N1,N3-Disubstituted 5-Methyl- and 5-Chlorobenzimidazolines

The pyrolysis of 2-aryl-1-benzyl-3,5-dimethyl(I)-, 5-chloro-3-methyl(II)-, 3-substituted-benzyl-5-methyl(III)- and 3-substituted-benzyl-5-chloro-(IV)-benzimidazolines has been carried out to study the orientation of their elimination reactions.The benzyl group is eliminated in preference to methyl in benzimidazolines of the types (I) and (II) irrespective of the nature of the substituent in phenylene and aryl moieties.The course of the elimination reaction in compounds of the types (III) and (IV) appears to be determined by the relative stabilities of benzyl and substituted benzyl radicals.The structures of the pyrolysis products have been established on the basis of spectral and chemical evidences.